Which of the following statements is true about genetic disorders?

A、Carriers with chromosomal balanced translocation generally have no phenotype, but infertility, miscarriage and fetal malformations may occur during childbirth;
B、Patients with genetic diseases must have a family history, but no de novo mutation;
C、The pathogenic gene of X-linked recessive genetic diseases is located on the X chromosome and is dominant;
D、Genetic disease is diagnosed by molecular biology techniques such as microarrays and PCR, through the DNA molecular level