Hemolytic disease of the newborn will occur at

A、Rh-mother 1st pregnancy, Rh+ newborn; ‍;
B、Rh+ mother 1st pregnancy, Rh- newborn;;
C、Rh- mother 2ed pregnancy, Rh+ newborn;‍‍;
D、Rh-mother 2ed pregnancy, Rh- newborn;