What is the best title among the following 4 titles for a research paper?

A、Social determinants of health: the role of effective communication in the COVID-19 pandemic in developing countries;

B、The role of effective communication in the COVID-19 pandemic in developing countries;

C、Social determinants of health and the role of effective communication in the COVID-19 pandemic in developing countries;

D、Effective communication in the COVID-19 pandemic in developing countries