Regarding the origin of replication in eukaryotic organisms, which are correct（ ）

A、There are multiple replication initiation sites in multicellular organisms, and the distribution in the genome is not random.;

B、Only a few replication initiation sites play a role in genome replication, which may be related to factors such as chromosome structure, gene transcription, biological development, and DNA methylation.;

C、 The replication start site can determine the time sequence of genome replication in S phase.;

D、
D、 The efficiency and start time of copying the start site at different sites are the same